IMAGING IMMUNITY – from Nanoscale to Macroscale | Insights from Biophysics
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Invited Lecture | Dario Neri, Zurich

Session chair: Twan Lammers (Aachen, Germany)
 
Date: Wednesday, 15 January, 2020, 4:15 PM - 5:00 PM

Contents

4:15 PM -01

Imaging and Biodistribution Analysis: a Crucial Tool for the Development of Targeted Therapeutics (#41)

Dario Neri1

1 ETH Zürich, Chemistry, Zurich, Switzerland

Content

There is a trend in "arming" antibodies with bioactive payloads for the therapy of cancer and of chronic inflammatory conditions. Popular payloads include drugs, radionuclides, cytokines, bispecific antibodies and CAR-Ts.

In this lecture, I will show how we have validated the targeting ability of antibodies and of small molecules, first in mouse models and later in patients, as a pre-requisite for the development of targeted therapeutics.

I will also discuss the impact that targeting can have on the improvement of the therapeutic index of biopharmaceuticals, with a special focus on cytotoxic drugs and on pro-inflammatory cytokines.

References

Acknowledgement

Keywords: PET, SPECT, Optical Imaging, Antibody-cytokine fusions, Small molecule-drug conjugates