Abstract/Video opens by clicking at the talk title.
|3:45 p.m.||SG 04-01||
Summary of work in subgroups / current status of standardization efforts (#658)
1 Amsterdam University Medical Centre, location VUMC, Radiology and Nuclear Medicine, Amsterdam, Netherlands
A summary of the work done within the study group will be presented. In addition, the goals of the study group and the work plan for the coming year will be discussed.
- Mannheim JG, Mamach M et al., 2019, 'Reproducibility and Comparability of Preclinical PET Imaging Data: A Multicenter Small-Animal PET Study', J Nucl Med 60(10):2483-1491
McDougald W, Vanhove C et al., 2020, 'Standardization of Preclinical PET/CT Imaging to Improve Quantitative Accuracy, Precision and Reproducibility: A Multicenter Study, J Nucl Med 61(3):461-468
Keywords: Standardization, preclincal imaging
Standardization in small animal imaging (#690)
1 AIT Austrian Institute of Technology GmbH, Preclinical Molecular Imaging, Seibersdorf, Austria
Small animal imaging has evolved from a technique perceived to be niche and of limited value to an established workhorse in medical research, supporting drug discovery programs, mechanistic studies focused on understanding (patho-)physiology and disease development as well as progression, and aiding the development of paradigms for clinical imaging. Small animal imaging also encompasses scales of different order of magnitude, from molecular/microscopic to structural/macroscopic as well as organismic scale, thus providing not only excellent anatomical detail but also quantitative functional information. Despite the tremendous and ever-expanding role of small animal imaging in medical research, its full potential can only be delivered if preclinical researchers apply the same amount of effort and rigor to their preclinical protocols as is used in clinical settings. This means that standardization of small animal imaging is of paramount importance to generate preclinical imaging datasets with translational value.
This talk will give an overview of the current status of standardization in small animal imaging. This will include standardization recommended for animals as well as for phantom studies.
1) D. Stout et al. Guidance for methods descriptions used in preclinical imaging papers (Molecular Imaging, 2013, 12(7):1-15)
2) D.R. Osborne et al. Guidance for efficient smal animal imaging quality control (Mol Imaging Biol 2017, 19(4):485-498)
3) C. Kilkenny et al. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research (PLOS Biol 2010, 8:e1000412)
4) A.J. Smith et al. PREPARE: guidelines for planning animal research and testing ((Laboratory Animals 2018, Vol. 52(2) 135–141)
Keywords: small animal imaging, standardization
|4:30 p.m.||SG 04-03||
Subsequent LIVE Roundtable Discussion (#738)
Adriana Tavares1, Marc Huisman2
1 University of Edinburgh, Edinburgh, United Kingdom
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Keywords: study group