15th European Molecular Imaging Meeting
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How Life Science Research Infrastructures can Support your Research

Session chair: Giuseppe Digilio (Alessandria, Italy); Silvio Aime (Torino, Italy)
 
Shortcut: PRO 01
Date: Tuesday, 25 August, 2020, 10:30 a.m. - 12:00 p.m.
Session type: Project Session

The European Life Science Research Infrastructures (LS RIs) were established to overcome a technology gap and to allow access to much-needed technologies in modern research approaches. They have the mission to support cutting-edge science by offering access to the latest technologies, comprehensive resource collections and technical expertise. The European Life Science Research Infrastructures (LS RIs) play a central, facilitating role in this ground-breaking research by offering access to their resources to researchers from academia and industry, as demonstrated in both the Horizon 2020 CORBEL project and EOSC-Life.

This session will give insights into the following RIs: Euro-Bioimaging ERIC, INSTRUCT, EATRIS, BBMRI, and INFRAFRONTIER. The complementary expertise and opportunities these RIs offer to both academic and industrial biomedical research will also be described. The Greek Bioimaging Community will also present its operation and initiatives at the national and international levels.

Contents

Abstract/Video opens by clicking at the talk title.

10:30 a.m. PRO01-01

How Life Science Research Infrastructures can support your research

Giuseppe Digilio1

1 Università del Piemonte Orientale "A. Avogadro", DISIT, Alessandria, Italy

Content

The European Life Science Research Infrastructures (LS RIs) were established to overcome a technology gap and to allow access to much-needed technologies in modern research approaches. They have the mission to support cutting-edge science by offering access to the latest technologies, comprehensive resource collections and technical expertise.  The European Life Science Research Infrastructures (LS RIs) play a central, facilitating role in this ground-breaking research by offering access to their resources to researchers from academia and industry, as demonstrated in both the Horizon 2020 CORBEL project and EOSC-Life.

This session will give insights into the following RIs: Euro-Bioimaging  ERIC, INSTRUCT, EATRIS, BBMRI, and INFRAFRONTIER. The complementary expertise and opportunities these RIs offer to both academic and industrial biomedical research will also be described. The Greek Bioimaging Community will also present its operation and initiatives at the national and international levels.

Keywords: ERIC, open access, life sciences, research infrastructures, European Research Infrastructure Consortium
10:35 a.m. PRO01-02

Euro-BioImaging ERIC - Gateway to european excellence in biomedical and biomedical imaging

Giuseppe Digilio1

1 Università del Piemonte Orientale, DISIT, Alessandria, Italy

Content

Euro-Bioimaging ERIC is a pan-European, distributed infrastructure with operating facilities in 15 countries and the EMBL, providing access to cutting-edge technologies, training and data services in the field of advanced light microscopy and biomedical imaging (www.eurobioimaging.eu). General information about the Infrastructure and a description of Nodes, available technologies and services and access procedure will be provided.

Keywords: ERIC, Research Infrastructure, EuroBioimaging, open access, BioImaging
10:50 a.m. PRO 01-03

Instruct-ERIC

Jiri Novacek1, Naomi Gray2

1 Masaryk University, CEITEC, Brno, Czech Republic
2 Instruct, Oxford, United Kingdom

Content

Instruct-ERIC is a pan-European distributed research infrastructure making high-end technologies and methods in structural biology available to users. Instruct-ERIC is comprised of 14 member countries, one member international organisation (EMBL), and one observer country (Greece).

Our aim is to promote innovation in biomedical science through provision of the access to the state-of-the-art instrumentation and expertise for structural biology research. Instruct-ERIC provides open access to cutting edge structural biology, specifically supporting research that uses integrated approaches and technologies. The access to infrastructure, expertise, and methods is available to academic and industry researchers from all countries.

Instruct-ERIC is also supporting education of the researchers in structural and cell biology with the aim in raft in the technologies not just one specialism. The Instruct Training Program comprises a set of hands on workshops delivered by internationally recognised experts to cover a broad range of structural biology techniques and processes. In addition, Instruct-ERIC provides funding for pilot studies throu its R&D Pilot Research Award with the aim to help the researchers to obtain preliminary data which will serve as basis for the grant submission to national or international funding bodies. Finally, Instruct-ERIC is supporting the interships among the member laboratories to extend the qualifications of the laboratory staff and expand the availability of the state-of-the-art structural and cell biology techniques.

AcknowledgmentThis work was supported by Instruct-ERIC, Instruct-Ultra (Grant 731005), and iNEXT-Discovery (Grant 871037) funded by Horizon 2020 program of the European Commission.
Keywords: Instruct-ERIC, research infrastructure, cryo-EM
11:05 a.m. PRO01-04

EATRIS - the European Infrastructure for Translational Medicine

Martin de Kort1

1 EATRIS, Coordination Office, Amsterdam, Netherlands

Content

EATRIS focuses on clinical translation and provides user access to advanced molecular imaging capacities and promotes collaboration with industry, SME and academic institutions. Through case studies an overview will be presented on how EATRIS works for its users and its members (www.eatris.eu).

Translational research is a highly multi-disciplinary and complex undertaking. As a consequence, a major challenge in developing new innovations is understanding what steps need to be taken, and what expertise and technologies are suitable to perform these steps. Researchers in need of specialised support can approach EATRIS to provide guidance in the steps to be taken, by means of clinical, biological and technological expertise available within the infrastructure. Subsequently, EATRIS will match the need with the capabilities within the infrastructure. In this way, EATRIS facilitates collaboration among academics, physicians, and developers.

EATRIS helps you de-risk and add value to your drug, vaccine or diagnostic development programme. We do this by providing fast, tailored access to cutting-edge enabling technologies in translational research.

EATRIS is a non-profit European Research Infrastructure Consortium (ERIC). This specific legal form is designed to facilitate the joint establishment and operation of research infrastructures of European interest. EATRIS’s organisational model is based on country membership. Our institutions are selected within each country on the basis of their track record in public-private collaboration in the translational development and their multidisciplinary teams of leading academic experts, high-end research facilities, production laboratories and licenses.

EATRIS Logo
Keywords: European Research Infrastructure Consortium, EATRIS ERIC, Life Science Research infrastructure, Bioimaging, Translational Medicine
11:20 a.m. PRO01-05

INFRAFRONTIER – Resources and Services Towards Understanding of Human Health and Disease Using Mammalian Models

Asrar Ali Khan1, Michael Raess1

1 INFRAFRONTIER GmbH, Munich, Germany

Content

INFRAFRONTIER is the European Research Infrastructure for the development, phenotyping, archiving and distribution of mammalian models. INFRAFRONTIER provides access to first-class resources and services for biomedical research that include access to physical procedures and resources (model development, archiving and distribution), analytical platforms (systemic and specialized phenotyping), knowledge (training schools) and scientific data (genetic and phenotypic data). Therefore, contributing to improved understanding of gene functions from mouse to human. The INFRAFRONTIER network of 29 partners is engaged in several EC funded projects, such as INFRAFRONTIER2020, EJP-RD, CORBEL and EOSC-Life, and contributes to the efforts of the International Mouse Phenotyping Consortium (IMPC).

The core services of INFRAFRONTIER comprise model generation, systemic phenotyping of mouse mutants in the participating mouse clinics, as well as archiving and distribution of mouse mutant lines by the European Mouse Mutant Archive (EMMA). In addition, INFRAFRONTIER offers specialized services, such as germ-free mouse generation, training in state-of-the-art cryopreservation and phenotyping technologies. Reduction and refinement to improve animal welfare are among the major goals of INFRAFRONTIER’s technology development activities.

The EMMA branch of INFRAFRONTIER offers the worldwide scientific community a free archiving service for mutant mouse lines and access to a wide range of disease models and other research tools. EMMA currently holds over 7500 mutant mouse strains, half of which have been produced from the International Mouse Knockout Consortium (IKMC) resource. The EMMA network is comprised of 16 partners from 13 countries who operate as the primary mouse repository in Europe and is funded by the partner institutions and national research programmes. Information on mouse strain submission and ordering and all other services offered by INFRAFRONTIER can be accessed online at www.infrafrontier.eu.

INFRAFRONTIER Principles

INFRAFRONTIER offers a consistent European infrastructure for the research with mammalian models to a global user community – and simultaneously sets standards in caring for animal welfare.

Mutant Mouse Lines for the Global Scientific Community

As part of INFRAFRONTIER the European Mouse Mutant Archive (EMMA) offers free of charge archiving and access to more than 7500 mutant mouse lines.

Keywords: Research Infrastructure, Mouse models, phenotyping, cryopreservation
11:35 a.m. PRO01-06

How life science research infrastructures can support your research - BBMRI-ERIC

Francesco Florindi1

1 BBMRI-ERIC, Graz, Austria

Content

The European Life Science Research Infrastructures (LS RIs) were established to overcome a technology gap and to allow access to much-needed technologies in modern research approaches. They have the mission to support cutting-edge science by offering access to the latest technologies, comprehensive resource collections and technical expertise. The European Life Science Research Infrastructures (LS RIs) play a central, facilitating role in this ground-breaking research by offering access to their resources to researchers from academia and industry, as demonstrated in both the Horizon 2020 CORBEL project and EOSC-Life.

This session will give insights into the following RIs: Euro-Bioimaging ERIC, INSTRUCT, EATRIS, BBMRI, and INFRAFRONTIER. The complementary expertise and opportunities these RIs offer to both academic and industrial biomedical research will also be described. The Greek Bioimaging Community will also present its operation and initiatives at the national and international levels.

- Euro-Bioimaging ERIC is a pan-European, distributed infrastructure with operating facilities in 15 countries and the EMBL, providing access to cutting-edge technologies, training and data services in the field of advanced light microscopy and biomedical imaging (www.eurobioimaging.eu).

- Instruct is a pan-European research infrastructure in structural biology, making high-end technologies and methods available to all European researchers. Structural Biology is currently in the middle of a revolution enabled by significant advances in the available tools (www.instruct-eric.eu).

- EATRIS focuses on clinical translation and provides user access to advanced molecular imaging capacities and promotes collaboration with industry, SME and academic institutions. Through case studies an overview will be presented on how EATRIS works for its users and its members (www.eatris.eu).

- BBMRI-ERIC stands for “Biobanking and BioMolecular resources Research Infrastructure – European Research Infrastructure Consortium”. 19 European countries (and the World Health Organisation’s International Agency for Research on Cancer joined forces to establish BBMRI-ERIC as a research infrastructure, providing services and connecting biobanks across Europe. BBMRI-ERIC’s main mission is to facilitate access to samples and connected data. It provides support and services to local biobanks via BBMRI National Nodes (one per country) (www.bbmri.eu).

- INFRAFRONTIER is the European Research Infrastructure (RI) for generating, phenotyping, archiving and distributing genetically modified mouse models for medical research. It is a distributed consortium of biomedical research institutions with 29 partners in 15 European countries with thousands of scientific users in more than 50 countries worldwide (www.infrafrontier.eu).

- BioImaging-GR is a Greek research infrastructure for visualizing and monitoring fundamental biological processes by offering access to state of the art bioimaging facilities (www.bioimaging.gr).

Keywords: European Research Infrastructure Consortium, BBMRI, life sciences, research infrastructures, biobanking
11:50 a.m. PRO01-07

BIOIMAGING-GR: A Greek Research Infrastructure for Visualizing and Monitoring Fundamental Biological Processes

Giannis Zacharakis1

1 FORTH, IESL, Heraklion, Greece

Content

BioImaging-GR is a distributed Research Infrastructure for open-access, high-end biological imaging providing a range of imaging methods to scientists in Greece, the neighboring countries and Europe.

BioImaging-GR is built around a central coordinating Hub, serving as a single point of entry to the national infrastructure, and distributed partner Nodes that provide access to high-end Bioimaging instrumentation and services in a coordinated and harmonized manner, by pursuing the following 3 main objectives:

  1. Expand existing and establish new BioImaging facilities, such as next-generation fluorescence microscopy, electron microscopy (both TEM and SEM), PET, Micro-CT, fMRI, intravital imaging, microfluidics, ratiometric imaging, super-resolution microscopy and others.
  2. Provide training and imaging services to the research community and industrial users in Greece and neighboring countries using cutting-edge BioImaging technologies.
  3. Enhance the research and innovation potential of the Greek biomedical research community by networking and coordinating existing facilities, which operate at different centers, towards maximum complementarity and minimum redundancy.
The BioImaging-GR initiative will pool, exploit and expand existing resources to create state-of-the-art facilities for advanced biological imaging. These facilities will be accessible by / provide expertise to the entire research community of the region, including research establishments, educational establishments and SMEs. In addition, BioImaging-GR will provide access to “beyond state-of-the-art” imaging technologies, which are not easily accessible to the broader imaging community.
AcknowledgmentThis work was supported by the projects BIOIMAGING-GR (MIS5002755), funded by the Operational Programme "Competitiveness, Entrepreneurship and Innovation" and co-financed by Greece and the European Union
Keywords: Research Infrastructure, Advanced Imaging facilities, Microscopy, Hybrid microscopy, Open Access policy