15th European Molecular Imaging Meeting
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VASILIS NTZIACHRISTOS, Munich | Looking and Listening to Tissue: Advances in Fluorescence and Optoacoustic Bio-Imaging

Session chair: Giannis Zacharakis (Heraklion, Greece); Frauke Alves (Goettingen, Germany)
 
Shortcut: PL 01
Date: Wednesday, 26 August, 2020, 9:00 a.m. - 9:45 a.m.
Session type: Plenary Session

Vasilis is dedicating his Opening Lecture in memoriam of Sanjiv Sam Gambhir and Moritz F. Kircher - they will be dearly missed.

Contents

Abstract/Video opens by clicking at the talk title.

9:00 a.m. PL 01-01

Looking and Listening to Tissue: Advances in Fluorescence and Optoacoustic Bio-imaging

Vasilis Ntziachristos1, 2

1 Helmholtz Zentrum München, Institute for Biological and Medical Imaging, Munich, Germany
2 Technische Universität München, School of Medicine and School of Electrical Engineering, Munich, Germany

Content

Optical and optoacoustic imaging have now progressed beyond critical boundaries in contrast and penetration depth of optical methods, enabling the use of light for a variety of research and clinical applications. The talk discusses advances in multi-spectral opto-acoustic tomography (MSOT) and optoacoustic mesoscopy and microscopy that impart unprecedented optical imaging performance in visualizing anatomical, physiological and molecular biomarkers in-vivo. In particular, we illuminate how MSOT visualizes biomarkers that relate to inflammatory and metabolic processes in a safe and portable manner, and the role of these biomarkers in addressing unmet clinical needs. Applications including imaging of breast cancer, brown fat activation or inflammatory conditions of the skin and bowels are showcased as examples of the clinical potential. We discuss how MSOT is appropriate for disseminated, frequent and longitudinal imaging, and how applications in hybrid mode, together with ultrasonography, offer novel potential for advancing diagnostics and theranostics. We further highlight recent progress in the label-free imaging of molecules using Mid-IR Optoacoustic Microscopy (MiROM), a novel modality that pushes the limits of visualization in optical microscopy. Finally, we discuss progress in fluorescence molecular imaging (FMI), which not only has the potential to improve surgical procedures, but now also contributes to early diagnostics.

Keywords: optoacoustic bio-imaging, fluorescence imaging, MSOT